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Alzheimer’s Disease

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Abbiati G, Fossati T,  Lachmann G, Bergamaschi M, Castiglioni C. (1993) Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Eur. J. Drug Metab. Pharmacokinet. 18, 173-180.

Arai T, Gupte PM, Lasker SE, Del Guercio LR, Mori K. (1989) Method for the detection of tissue metabolite (H2(17)O) in brain by proton magnetic resonance imaging. Crit. Care Med. 17, 1333-1334.

Charagundla SR, Duvvuri U, Noyszewski EA, Dandora R, Stolpen AH, Leigh JS, Reddy R. (2000) 17O-decoupled (1)H spectroscopy and imaging with a surface coil: STEAM decoupling. J. Magn. Reson.  143, 39-44.

Kanfer JN, Pettegrew JW, Moossy J and McCartney DG (1993) Alterations of selected enzymes of phospholipid metabolism in Alzheimer’s disease brain tissue as compared to non-Alzheimer’s disease controls. Neurochem. Res. 18, 331-334.

Klunk WE, Panchalingam K, McClure RJ and Pettegrew JW (1996) Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer’s disease brain. Neurobiol. Aging 17 , 349-357.

Klunk WE, Xu CJ, McClure RJ, Panchalingam K, Stanley JA, Pettegrew JW. (1997) Aggregation of b-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brain. J. Neurochem. 69, 266-272.

Kwong KK, Hopkins AL,  Belliveau JW, Chesler DA, Porkka LM, McKinstry RC, Finelli DA, Hunter GJ, Moore JB, Barr RG. (1991) Proton NMR imaging of cerebral blood flow using H2(17)O. Magn. Reson. Med. 22, 154-158.

Mandal PK, McClure RJ and Pettegrew JW (2004) Interactions of Abeta(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescence and circular dichroism studies. Neurochem. Res. 29, 2273-2279.

McClure RJ, Panchalingam K, Stanley JA, Pettegrew JW (2001) Molecular modeling of glycerophosphocholine with an amyloid beta(1-28) peptide fragment, Society for Neuroscience. Abstracts27, abstract 322.9.

Pettegrew JW, Minshew NJ, Cohen MM, Kopp SJ and Glonek T (1984) P-31 NMR changes in Alzheimer’s and Huntington’s disease brain. Neurology 34(Suppl 1), 281.

Pettegrew JW, Withers G, Panchalingam K and Post JF (1987) 31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer’s disease. Journal of Neural Transmission Suppl. 24, 261-268.

Pettegrew JW, Moossy J, Withers G, McKeag D and Panchalingam K (1988a) 31P Nuclear Magnetic Resonance study of the brain in Alzheimer’s disease. Journal of Neuropathology Experimental Neurology 47, 235-248.

Pettegrew JW, Panchalingam K, Moossy J, Martinez J, Rao G and Boller F (1988b) Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer’s disease. Archives of Neurology 45, 1093-1096.

Pettegrew JW, Panchalingam K, Withers G, McKeag D and Strychor S (1990) Changes in brain energy and phospholipid metabolism during development and aging in the Fischer 344 rat. J. Neuropathol. Exp. Neurol. 49, 237-249.

Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ and Muenz LR (1994) Alterations of cerebral metabolism in probable Alzheimer’s disease:  A preliminary study. Neurobiology of Aging 15, 117-132.

Pettegrew JW, Klunk WE, Kanal E, Panchalingam K and McClure RJ (1995a) Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia. Neurobiology of Aging 16, 973-975.

Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JN and McClure RJ (1995b) Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer’s disease. Neurobiology of Aging 16, 1-4.

Pettegrew JW, Klunk WE, Panchalingam K, McClure RJ and Stanley JA (2000a) Molecular insights into neurodevelopmental and neurodegenerative diseases. Brain Research Bulletin 53, 455-469.

Pettegrew JW, Levine J and McClure RJ (2000b) Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties:  Relevance for its mode of action in Alzheimer’s disease and geriatric depression. Molecular Psychiatry 5, 616-632.

Pettegrew JW, Panchalingam K, Hamilton RL and McClure RJ (2001) Brain membrane phospholipid alterations in Alzheimer’s disease. Neurochemcal Research 26, 771-782.

Pettegrew JW, Panchalingam K and McClure RJ (2002) 31P – 1H MRS study of membrane phospholipid metabolism in AD.  2002 Abstract Viewer/Itinerary Planner, Society for Neuroscience, Program No. 228.2.

Pettegrew JW, Mandal PK, Panchalingam K and McClure RJ (2005) Catalytic breakdown of glycerophosphocholine by Abeta peptide Program No. 704.9, Society for Neuroscience, Online, Washington, DC.

Sullivan MG (2005) U.K. Considers pulling four antidementia drugs. Clinical Psychiatry News 33, 1-2.

U.S. General Accounting Office, GAO/HEWS-98-16, Washington, DC, pp. 1-45, 1998.