23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease

Share with one of the following

23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease

To view the full article click here to login

J.W Pettegrew and D.E. Woessner

I. Introduction
A. Sodium Biology
The regulation of Na+ trans-membrane fluxes and intracellular Na+
concentrations, is of fundamental importance to human biological processes.
Exchange processes serve to alter the chemical state of the ion and the
position of carefully controlled equilibria. Alterations in Na+ trans­
membrane unidirectional rate constants with resultant alterations in
intracellular Na+ concentration have been implicated in a number of human
disease processes such as cystic fibrosis (Sorscher et al 1982; Katz 1978;
Taylor et al 1979), essential hypertension (Clegg et al 1982; Canessa et al
1980; Duhm et al 1982; Garay et al 1980; Davidson et al 1982; Blaustein
1977), manic-depressive disease (Naylor et al 1976; Pandey et al 1977; Dorus
et al 1979), and cellular proliferative responses during mitogenesis and
oncogenesis (Cone et al 1971; Cameron et al 1980; Koch et al 1979; Rozenquat
et al 1980).

To view the full article click here to login