Molecular neurodevelopment: An in vivo31P-1H MRSI study

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Molecular neurodevelopment: An in vivo31P-1H MRSI study To view the full article click here to login Gerald Goldstein1, Kanagasabai Panchalingam2, Richard J. McClure2, Jeffrey A. Stanley6,Vince D. Calhoun7,8, Godfrey D. Pearlson9, and Jay W. Pettegrew2,3,4,5 1 VA Pittsburgh Healthcare System, Pittsburgh, PA2 Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh,Pittsburgh, PA3…

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Developmental Aspects and Neurobiological Correlates of Working and Associative Memory

Objective: It has been shown that verbal working and associative memory have different developmental trajectories with working memory, taking a linear course from early childhood to adolescence, whereas associative memory takes a curvilinear course asymptoting at about age 12. This study made a determination of whether these trajectories tracked with 2 magnetic resonance spectroscopy imaging (MRSI) variables: phosphocreatine level (PCr) and gray matter percentage (GM%).

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